resulting in oxidative stress

It is also reported that antioxidants may be important in controlling the severity of RA, reducing joint inflammation and connective tissue damage.28 The infiltration of blood-derived cells into the affected joints and their activation in AR generate reactive oxygen / nitrogen species, resulting in oxidative stress, so the use of antioxidants helps to counteract this disease.

The animal models of AR are used to investigate the pathogenesis of the disease and to evaluate potential anti-arthritic drugs. There are important criteria in the selection of animal models, such as: 1) their ability to predict the efficacy of the agents evaluated in humans, 2) the ease of carrying out the model, reproducibility of the data Flekosteel, duration of the trial period and 3) the similarity in the disease and / or pathogenesis with that of the human.